Author(s)
Sebastien Casault, Martin Kenward, Gary W Slater
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Title
Combinatorial design of passive drug delivery platforms
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Publication Name
International Journal of Pharmaceutics
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Publication Type
Journal
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Publisher
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Place
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Editor(s)
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Number
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School
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Volume
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Chapter
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Pages
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Other Publication Information
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Publication Year
2007
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Abstract
We introduce a novel computational approach to designing passive drug delivery systems based on porous materials such as hydrogels. Our approach uses three tools: a method to establish the exact release pattern from all possible loading sites inside a given hydrogel; a method to generate a large number of hydrogel structures to be tested numerically, and finally an optimization algorithm which leads to the selection of optimal hydrogel structures. Using this approach, we show that controlled release curves can be obtained by using a genetic algorithm for the optimization step. Strategies to generalize this approach to other systems are also discussed.
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Keywords
Drug Delivery
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Website
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Paper Status
Accepted
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DOI / Publication ID
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