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Author(s)
     P. M. Mayer , E. Martineau
Title
     Gas-phase binding energies for non-covalent Ab-40 peptide/small molecule complexes from CID mass spectrometry and RRKM theory
Publication Name
     Phys Chem Chem Phys.
Publication Type
     Journal
Publisher
     
Place
     
Editor(s)
     
Number
     
School
     
Volume
      13
Chapter
     
Pages
      5178 - 5186
Other Publication Information
     
Publication Year
     2011
Abstract
     The gas-phase binding of small molecules to the Amyloid b-40 peptide generated by electrospray ionization has been explored with collision-induced dissociation mass spectrometry and kinetic rate theory. This study discusses a simple procedure used to theoretically model the experimental breakdown diagrams for the Ab-40 peptide complexed with a series of aminosulfonate small molecules, namely homotaurine, 3-cyclohexylamino-2-hydroxy-1-propanesulfonic acid (CAPSO), 3-(1,3,4,9-tetrahydro-2H-b-carbolin-2-yl)propane-1-sulfonic acid, 3-(1,3,4,9-tetrahydro- 2H-b-carbolin-2-yl)butane-1-sulfonic acid, and 3-(cyclohexylamino)propane-1-sulfonic acid. An alternative procedure employing an extrapolation procedure for k(E) is also discussed.
Keywords
     RRKM theory, CID mass spectrometry, Aβ-peptide, Aβ-peptide and small reagents, small reagents
Website
     http://pubs.rsc.org/en/content/articlepdf/2011/cp/c0cp02149k?page=search
Paper Status
     Published
DOI / Publication ID
     10.1039/C0CP02149K



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